Have a look at the yellow high-lighted "Fedora Set-Up Guides" link at the top of this forum.
In particular, EasyLife and/or AutoPlus will make your life easier. Check out Infinality (particularly http://www.infinality.net/blog/infinality-repository/
) if you want to make your screen fonts look much much nicer (way better than installing MS fonts!). Other than that, without knowing what sort of things you use your system for, it's difficult to suggest what else you might like to have over the basic default install.